Rituximab destroys both normal and malignant [[B cells]] that have CD20 on their surfaces, and is therefore used to treat diseases which are characterized by having too many B cells, overactive B cells or dysfunctional B cells. ===Hematological neoplastic diseases=== Rituximab is frequently used to treat [[Hematological malignancy|hematological neoplasms]] such as [[leukemia]]s and [[lymphoma]]s. In [[multiple myeloma]], treatment with rituximab fails to deplete circulating CD20+ B or plasma cells, even after up to four cycles of treatment; in some patients, rituximab treatment increases the number of circulating CD20+ B cells. [http://www.doaj.org/doaj?func=abstract&id=260717&recNo=32&toc=1/ Multiple myeloma includes CD20+ B and plasma cells that persist in patients treated with rituximab. LM Pilarski, E Baigorri, MJ Mant, PM Pilarski, P Adamson, H Zola, AR Belch. Clinical Medicine:Oncology, 2:275-281, 2008] ===Autoimmune diseases=== Rituximab has been shown to be an effective [[rheumatoid arthritis]] treatment in three randomised controlled trials and is now licensed for use in refractory rheumatoid disease.{{cite journal | author = Edwards J, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close D, Stevens R, Shaw T | title = Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis | journal = N Engl J Med | volume = 350 | issue = 25 | pages = 2572–81 | year = 2004 | pmid = 15201414 | doi = 10.1056/NEJMoa032534}} In the United States, it has been FDA-approved for use in combination with [[methotrexate]] (MTX) for reducing signs and symptoms in adult patients with moderately- to severely-active rheumatoid arthritis (RA) who have had an inadequate response to one or more anti-[[TNF-alpha]] therapies. [...]
Colorectal Cancer Breast Cancer Organ Rejection [...]
Transformer MovieTransformers is a 2007 live-action-thriller film adaptation of the Transformers franchise, directed by Michael Bay and written by John Rogers, Roberto Orci and Alex Kurtzman. It stars Shia LaBeouf as Sam Witwicky, a teenager involved in a war between the heroic Autobots and the evil Decepticons, two factions of alien robots who can disguise themselves by transforming into everyday machinery. The Decepticons desire control of the All Spark, the object that created their robotic race, with the intention of using it to build [...]
Max Payne is a BAFTA award winning[1] third-person shooter video game developed by Finnish Remedy Entertainment, produced by 3D Realms and published by Gathering of Developers in July 2001 for Windows. Ports later in the year for the Xbox, PlayStation 2 and the GameBoy Advance were published by Rockstar Games. A Macintosh port was published in July 2002 by MacSoft in[...]
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