Friday, December 31, 2010
Thursday, December 30, 2010
bubbl.us - free web application for brainstorming online [del.icio.us] http://bubbl.us/
bubbl.us - free web application for brainstorming online [del.icio.us] http://bubbl.us/
Friday, December 24, 2010
Maths Worksheets Key Stage 1 Multiplication Index - Project ... [del.icio.us] http://ping.fm/VO3ox
Maths Worksheets Key Stage 1 Multiplication Index - Project ... [del.icio.us] http://ping.fm/VO3ox
multiplication worksheets [del.icio.us] http://ping.fm/0tKC1
multiplication worksheets [del.icio.us] http://ping.fm/0tKC1
Tuesday, December 21, 2010
Monday, December 20, 2010
Ewan McIntosh | Digital Media & Learning: Creativity [del.icio.us] http://ping.fm/N1dez
Ewan McIntosh | Digital Media & Learning: Creativity [del.icio.us] http://ping.fm/N1dez
Fifty Dangerous Things [del.icio.us] http://ping.fm/Rt6DM
Fifty Dangerous Things [del.icio.us] http://ping.fm/Rt6DM
Wednesday, December 15, 2010
Express Publishing (ELT) English Language Teaching Home Page [del.icio.us] http://ping.fm/e1jKe
Express Publishing (ELT) English Language Teaching Home Page [del.icio.us] http://ping.fm/e1jKe
Monday, December 13, 2010
Kids Crafts, Activities, Coloring Pages & Printables ... [del.icio.us] http://ping.fm/OG9JB
Kids Crafts, Activities, Coloring Pages & Printables ... [del.icio.us] http://ping.fm/OG9JB
Shirley's Preschool Activities [del.icio.us] http://ping.fm/vquE2
Shirley's Preschool Activities [del.icio.us] http://ping.fm/vquE2
Thursday, December 9, 2010
Pearson Longman's [del.icio.us] http://ping.fm/foSWP
Pearson Longman's [del.icio.us] http://ping.fm/foSWP
Home - Pearson Longman [del.icio.us] http://ping.fm/fx1Kx
Home - Pearson Longman [del.icio.us] http://ping.fm/fx1Kx
Wednesday, December 8, 2010
Training | Ultimatehandbook [del.icio.us] http://ping.fm/sA6lC
Training | Ultimatehandbook [del.icio.us] http://ping.fm/sA6lC
Best Bones Forever! [del.icio.us] http://ping.fm/LzZQe
Best Bones Forever! [del.icio.us] http://ping.fm/LzZQe
Monday, November 29, 2010
The Little Talkatives [del.icio.us] http://ping.fm/iFuu4
The Little Talkatives [del.icio.us] http://ping.fm/iFuu4
What's Your Schema? - Oprah.com [del.icio.us] http://ping.fm/qGQ9O
What's Your Schema? - Oprah.com [del.icio.us] http://ping.fm/qGQ9O
Thinking Page: better thinking using systems thinking, creativity ... [del.icio.us] http://ping.fm/pkcqC
Thinking Page: better thinking using systems thinking, creativity ... [del.icio.us] http://ping.fm/pkcqC
Tuesday, November 23, 2010
Waters Foundation [del.icio.us] http://ping.fm/TD3i3
Waters Foundation [del.icio.us] http://ping.fm/TD3i3
Welcome to the Institute for Habits of Mind | Institute For Habits of Mind [del.icio.us] http://ping.fm/Zfqum
Welcome to the Institute for Habits of Mind | Institute For Habits of Mind [del.icio.us] http://ping.fm/Zfqum
Linda Booth Sweeney > Thinking About Systems > 12 Habits of Mind [del.icio.us] http://ping.fm/cQL43
Linda Booth Sweeney > Thinking About Systems > 12 Habits of Mind [del.icio.us] http://ping.fm/cQL43
Wednesday, November 17, 2010
Monday, November 15, 2010
Mabthera ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/LcYQ6
Mabthera ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/LcYQ6
Generosity on the Brain | Greater Good [del.icio.us] http://ping.fm/qTZcd
Generosity on the Brain | Greater Good [del.icio.us] http://ping.fm/qTZcd
The My Hero Project [del.icio.us] http://ping.fm/yWjl1
The My Hero Project [del.icio.us] http://ping.fm/yWjl1
Monday, November 8, 2010
peging techniques [del.icio.us] http://ping.fm/yJPxl
peging techniques [del.icio.us] http://ping.fm/yJPxl
Wednesday, November 3, 2010
Herceptin ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/vhmrE
Herceptin ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/vhmrE
Avastin ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/lmyZo
Avastin ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/lmyZo
Tuesday, November 2, 2010
Monday, November 1, 2010
CETUXIMAB ERBITUX ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/iMgcn
CETUXIMAB ERBITUX ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/iMgcn
Monday, October 25, 2010
WAITING FOR SUPERMAN ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/EHB0j
WAITING FOR SUPERMAN ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/EHB0j
Friday, October 22, 2010
How to Embed Almost Anything in your Website [del.icio.us] http://ping.fm/MQzxs
How to Embed Almost Anything in your Website [del.icio.us] http://ping.fm/MQzxs
Thursday, October 21, 2010
Nexavar sorafenib 200mg ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/iz58G
Nexavar sorafenib 200mg ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/iz58G
Wednesday, October 20, 2010
Bondronat (Ibandronate) ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/y76W5
Bondronat (Ibandronate) ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/y76W5
ZENAPAX ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/8kSDE
ZENAPAX ~ Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/8kSDE
Tuesday, October 19, 2010
Add Social Bookmarking Buttons/Icons Below Blogger Posts | Everything ... [del.icio.us] http://ping.fm/4V5xJ
Add Social Bookmarking Buttons/Icons Below Blogger Posts | Everything ... [del.icio.us] http://ping.fm/4V5xJ
Blueberry Cornmeal Pancakes [del.icio.us] http://ping.fm/CckA6
Blueberry Cornmeal Pancakes [del.icio.us] http://ping.fm/CckA6
Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/KMyOT
Leading Suppliers Of Critical Care Therapeutics [del.icio.us] http://ping.fm/KMyOT
Friday, October 15, 2010
leading suppliers of critical care therapeutics http://ping.fm/gJSPR
leading suppliers of critical care therapeutics http://ping.fm/gJSPR
Tuesday, October 12, 2010
Whooping Cough
Sanofi-Aventis gets tired of waiting, so now they're barking up a different tree, but will it work?
- The biotech landscape seems to be shrinking, but is it just an illusion? We'll take a look.
- Whooping cough is making a comeback. Find out how one state is trying to fight this resurgence
Sanofi-Aventis gets tired of waiting, so now they're barking up a different tree, but will it work?
- The biotech landscape seems to be shrinking, but is it just an illusion? We'll take a look.
- Whooping cough is making a comeback. Find out how one state is trying to fight this resurgence
Monday, October 11, 2010
Avastin Bevacizumab
Available At wholesale
Available At wholesale
Bevacizumab was approved by the FDA in February 2004 for use in metastatic colorectal cancer when used with standard chemotherapy treatment (as first-line treatment) and with 5-fluorouracil-based therapy for second-line metastatic colorectal cancer. This recommendation was based on E3200 trial - addition of bevacizumab to oxaliplatin/5-FU/leucovorin (FOLFOX4) therapy. It was approved by the EMEA in January 2005 for use in colorectal cancer.
In 2006, the FDA approved bevacizumab for use in lung cancer in combination with standard first-line chemotherapy. A study conducted by the Eastern Cooperative Oncology Group (ECOG) demonstrated a 2-month improvement in overall survival in patients with Stage IIIb/IV non-small cell lung cancer (NSCLC). Due to the observance of severe pulmonary hemorrhage in patients with NSCLC with squamous histology in an earlier study, patients with such histology were excluded from the pivotal ECOG trial.
In 2008, the FDA approved Bevacizumab for use in breast cancer. A panel of outside advisers voted 5 to 4 against approval, but their recommendations were overruled. The panel expressed concern that data from the clinical trial did not show any increase in quality of life or prolonging of life for patients - two important benchmarks for late-stage cancer treatments. The clinical trial did show that bevacizumab reduced tumor volumes and showed an increase in progression free survival time. It was based on this data that the FDA chose to overrule the recommendation of the panel of advisers. This decision was lauded by patient advocacy groups and some oncologists. Other oncologists felt that granting approval for late-stage cancer therapies that did not prolong or increase the quality of life for patients would give license to pharmaceutical companies to ignore these important benchmarks when developing new late-stage cancer therapies.[3] On March 28, 2007, the European Commission approved bevacizumab in combination with paclitaxel for the first-line treatment of metastatic breast cancer.[7]
Bevacizumab is usually given intravenously through the arm every 14 days. In colon cancer, it is given in combination with the chemotherapy drug 5-FU (5-fluorouracil), leucovorin, and oxaliplatin or irinotecan.
In 2009, the FDA approved Bevacizumab for use in metastatic renal cell cancer (a form of kidney cancer) which is the drug's sixth indication[8] [9], following earlier reports of activity[10]glioblastoma multiforme, a type of brain cancer.[11] and EU approval in 2007. Also in 2009, an FDA advisory committee unanimously recommended Bevacizumab for treatment of
In the September 2009 issue of the Journal of Clinical Oncology, UCLA researchers reported that Avastin improves response and survival in patients with recurrent glioblastoma in comparison to historical controls.[12] Avastin may also be useful in the treatment of radiation necrosis, since it reduces edema and mass effect and diminishes blood-brain-barrier leakage.
Bevacizumab did not meet its primary endpoint of extending overall survival (OS) in a recent phase III trial in unresectable gastric cancer (in combination with paclitaxel / Taxol), but it did demonstrate a positive result in treatment of ovarian cancer
Bevacizumab was approved by the FDA in February 2004 for use in metastatic colorectal cancer when used with standard chemotherapy treatment (as first-line treatment) and with 5-fluorouracil-based therapy for second-line metastatic colorectal cancer. This recommendation was based on E3200 trial - addition of bevacizumab to oxaliplatin/5-FU/leucovorin (FOLFOX4) therapy. It was approved by the EMEA in January 2005 for use in colorectal cancer.
In 2006, the FDA approved bevacizumab for use in lung cancer in combination with standard first-line chemotherapy. A study conducted by the Eastern Cooperative Oncology Group (ECOG) demonstrated a 2-month improvement in overall survival in patients with Stage IIIb/IV non-small cell lung cancer (NSCLC). Due to the observance of severe pulmonary hemorrhage in patients with NSCLC with squamous histology in an earlier study, patients with such histology were excluded from the pivotal ECOG trial.
In 2008, the FDA approved Bevacizumab for use in breast cancer. A panel of outside advisers voted 5 to 4 against approval, but their recommendations were overruled. The panel expressed concern that data from the clinical trial did not show any increase in quality of life or prolonging of life for patients - two important benchmarks for late-stage cancer treatments. The clinical trial did show that bevacizumab reduced tumor volumes and showed an increase in progression free survival time. It was based on this data that the FDA chose to overrule the recommendation of the panel of advisers. This decision was lauded by patient advocacy groups and some oncologists. Other oncologists felt that granting approval for late-stage cancer therapies that did not prolong or increase the quality of life for patients would give license to pharmaceutical companies to ignore these important benchmarks when developing new late-stage cancer therapies.[3] On March 28, 2007, the European Commission approved bevacizumab in combination with paclitaxel for the first-line treatment of metastatic breast cancer.[7]
Bevacizumab is usually given intravenously through the arm every 14 days. In colon cancer, it is given in combination with the chemotherapy drug 5-FU (5-fluorouracil), leucovorin, and oxaliplatin or irinotecan.
In 2009, the FDA approved Bevacizumab for use in metastatic renal cell cancer (a form of kidney cancer) which is the drug's sixth indication[8] [9], following earlier reports of activity[10]glioblastoma multiforme, a type of brain cancer.[11] and EU approval in 2007. Also in 2009, an FDA advisory committee unanimously recommended Bevacizumab for treatment of
In the September 2009 issue of the Journal of Clinical Oncology, UCLA researchers reported that Avastin improves response and survival in patients with recurrent glioblastoma in comparison to historical controls.[12] Avastin may also be useful in the treatment of radiation necrosis, since it reduces edema and mass effect and diminishes blood-brain-barrier leakage.
Bevacizumab did not meet its primary endpoint of extending overall survival (OS) in a recent phase III trial in unresectable gastric cancer (in combination with paclitaxel / Taxol), but it did demonstrate a positive result in treatment of ovarian cancer
Thursday, October 7, 2010
Rituximab(Mabthera)
Reactivation of hepatitis B virus (HBV) has been reported as a fatal complication following systemic chemotherapy or other immunosuppressive therapy. The risk of HBV reactivation differs according to both the patient's HBV infection status prior to systemic chemotherapy and the degree of immunosuppression due to chemotherapy. For establishing an optimal strategy for hepatitis prevention and treatment, it is necessary to understand the characteristics, the clinical course and the risk factors for HBV reactivation and to recognize the difference between hepatitis B surface antigen (HBsAg)-positive and -negative patients with HBV reactivation. Among the important viral risk factors, HBV-DNA level and HBV-related serum markers have been reported to be associated with HBV reactivation in addition to cccDNA, genotypes and gene mutations. Rituximab-plus-steroid combination chemotherapy has recently been identified as a host risk factor for HBV reactivation in hepatitis B core antibody (anti-HBc)-positive and/or hepatitis B surface antibody (anti-HBs) positive-but nonetheless HBsAg-negative-lymphoma patients. For these patients with resolved hepatitis B, preemptive therapy guided by serial HBV-DNA monitoring is a reasonable strategy to enable early diagnosis of HBV reactivation and initiation of antiviral therapy. In this review, we summarize the characteristics of HBV reactivation following rituximab-plus-steroid combination chemotherapy, mainly in HBsAg-negative lymphoma patients, and propose a strategy for managing HBV reactivation
Reactivation of hepatitis B virus (HBV) has been reported as a fatal complication following systemic chemotherapy or other immunosuppressive therapy. The risk of HBV reactivation differs according to both the patient's HBV infection status prior to systemic chemotherapy and the degree of immunosuppression due to chemotherapy. For establishing an optimal strategy for hepatitis prevention and treatment, it is necessary to understand the characteristics, the clinical course and the risk factors for HBV reactivation and to recognize the difference between hepatitis B surface antigen (HBsAg)-positive and -negative patients with HBV reactivation. Among the important viral risk factors, HBV-DNA level and HBV-related serum markers have been reported to be associated with HBV reactivation in addition to cccDNA, genotypes and gene mutations. Rituximab-plus-steroid combination chemotherapy has recently been identified as a host risk factor for HBV reactivation in hepatitis B core antibody (anti-HBc)-positive and/or hepatitis B surface antibody (anti-HBs) positive-but nonetheless HBsAg-negative-lymphoma patients. For these patients with resolved hepatitis B, preemptive therapy guided by serial HBV-DNA monitoring is a reasonable strategy to enable early diagnosis of HBV reactivation and initiation of antiviral therapy. In this review, we summarize the characteristics of HBV reactivation following rituximab-plus-steroid combination chemotherapy, mainly in HBsAg-negative lymphoma patients, and propose a strategy for managing HBV reactivation
Effect of Mycophenolate Mofetil on Cerulein-Induced Acute Pancreatitis
The aim of this study was to determine the effects of mycophenolate mofetil (MMF) on acute pancreatitis with evaluation of biochemical and histopathological findings. Materials and Methods: Cerulein was administered to induce acute pancreatitis in rats. Three groups of 10 rats each were formed. Animals in group 1 received physiologic saline solution. In group 2 animals received MMF at a dose of 14 mg/kg and group 3 had double doses of MMF. Alanine aminostransferase, aspartate aminotransferase (AST), amylase and bilirubin levels were assessed. Pancreatic tissues were evaluated under light microscopy for the presence of edema, acinar necrosis, hemorrhage, inflammation and perivascular infiltration. Results: Amylase, serum AST, edema and inflammatory infiltration levels differed between groups (amylase: p = 0.0001, serum AST: p = 0.001, edema: p = 0.0001 and inflammatory infiltration: p = 0.002), group 1 showing the highest amylase, serum AST and edema levels. The lowest levels of edema were found in group 3. Conclusion: In an experimental pancreatitis model in rats, MMF proved to exert a beneficial effect on biochemical and histopathological parameters
The aim of this study was to determine the effects of mycophenolate mofetil (MMF) on acute pancreatitis with evaluation of biochemical and histopathological findings. Materials and Methods: Cerulein was administered to induce acute pancreatitis in rats. Three groups of 10 rats each were formed. Animals in group 1 received physiologic saline solution. In group 2 animals received MMF at a dose of 14 mg/kg and group 3 had double doses of MMF. Alanine aminostransferase, aspartate aminotransferase (AST), amylase and bilirubin levels were assessed. Pancreatic tissues were evaluated under light microscopy for the presence of edema, acinar necrosis, hemorrhage, inflammation and perivascular infiltration. Results: Amylase, serum AST, edema and inflammatory infiltration levels differed between groups (amylase: p = 0.0001, serum AST: p = 0.001, edema: p = 0.0001 and inflammatory infiltration: p = 0.002), group 1 showing the highest amylase, serum AST and edema levels. The lowest levels of edema were found in group 3. Conclusion: In an experimental pancreatitis model in rats, MMF proved to exert a beneficial effect on biochemical and histopathological parameters
chemopreventive role of curcumin and resveratrol
Colorectal cancer (CRC) is a second leading cause of cancer deaths in the Western world. Currently there is no effective treatment except resection at a very early stage with or without chemotherapy. Of various epithelial cancers, CRC in particular has a potential for prevention, since most cancers follow the adenoma-carcinoma sequence, and the interval between detection of an adenoma and its progression to carcinoma is usually about a decade. However no effective chemopreventive agent except COX-2 inhibitors, limited in their scope due to cardiovascular side effects, have shown promise in reducing adenoma recurrence. To this end, natural agents that can target important carcinogenic pathways without demonstrating discernible adverse effects would serve as ideal chemoprevention agents. In this review, we discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC
Colorectal cancer (CRC) is a second leading cause of cancer deaths in the Western world. Currently there is no effective treatment except resection at a very early stage with or without chemotherapy. Of various epithelial cancers, CRC in particular has a potential for prevention, since most cancers follow the adenoma-carcinoma sequence, and the interval between detection of an adenoma and its progression to carcinoma is usually about a decade. However no effective chemopreventive agent except COX-2 inhibitors, limited in their scope due to cardiovascular side effects, have shown promise in reducing adenoma recurrence. To this end, natural agents that can target important carcinogenic pathways without demonstrating discernible adverse effects would serve as ideal chemoprevention agents. In this review, we discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC
Probiotic
The popularity of dairy products fortified with prebiotics and probiotics continues to increase as consumers desire flavorful foods that will fulfill their health needs. Our objectives were to assess the sensory profile of drinkable yogurts made with prebiotics and probiotics and to determine the viability of the probiotics in the yogurt drink over the duration of storage. Thirteen trained descriptive panelists evaluated 10 yogurt drinks on a 16-point category scale. Three selected prebiotics, soluble corn fiber, polydextrose, and chicory inulin, were each present individually at an amount to claim an excellent source of fiber (5 g of fiber/serving) or a good source of fiber (2.5 g of fiber/serving) in 6 different yogurt drinks. Three additional yogurt drinks contained 5 g of each of the separate prebiotics along with a mixture of the selected probiotics (Bifidobacterium lactis Bb-12 and Lactobacillus acidophilus LA-5). A control sample with no prebiotics or probiotics was also included in the experimental design. Data were analyzed by ANOVA, Fisher's least significant difference, and principal component analysis. Survival of the probiotics in the yogurt drinks during a 30-d refrigerated storage period was also analyzed. Results showed that clover honey aroma, buttermilk aroma, butter aroma, sweetness, sourness, chalky mouthfeel, and viscosity were identified as significant attributes in the yogurt drinks. Total variance explained by the principal component analysis biplot of factors 1 and 2 was 65%, which showed yogurt drinks with soluble corn fiber and inulin varying by the sweet versus sour attributes and yogurt drinks with polydextrose varying by the mouthfeel attributes. The viability study determined a 2- to 3-log decrease in the survival of probiotics in all of the yogurt treatments during a 30-d refrigerated storage period. Based on the results of the current study, only the polydextrose treatment would be an acceptable vehicle to deliver the probiotic health effects at the end of the 30-d storage period
The popularity of dairy products fortified with prebiotics and probiotics continues to increase as consumers desire flavorful foods that will fulfill their health needs. Our objectives were to assess the sensory profile of drinkable yogurts made with prebiotics and probiotics and to determine the viability of the probiotics in the yogurt drink over the duration of storage. Thirteen trained descriptive panelists evaluated 10 yogurt drinks on a 16-point category scale. Three selected prebiotics, soluble corn fiber, polydextrose, and chicory inulin, were each present individually at an amount to claim an excellent source of fiber (5 g of fiber/serving) or a good source of fiber (2.5 g of fiber/serving) in 6 different yogurt drinks. Three additional yogurt drinks contained 5 g of each of the separate prebiotics along with a mixture of the selected probiotics (Bifidobacterium lactis Bb-12 and Lactobacillus acidophilus LA-5). A control sample with no prebiotics or probiotics was also included in the experimental design. Data were analyzed by ANOVA, Fisher's least significant difference, and principal component analysis. Survival of the probiotics in the yogurt drinks during a 30-d refrigerated storage period was also analyzed. Results showed that clover honey aroma, buttermilk aroma, butter aroma, sweetness, sourness, chalky mouthfeel, and viscosity were identified as significant attributes in the yogurt drinks. Total variance explained by the principal component analysis biplot of factors 1 and 2 was 65%, which showed yogurt drinks with soluble corn fiber and inulin varying by the sweet versus sour attributes and yogurt drinks with polydextrose varying by the mouthfeel attributes. The viability study determined a 2- to 3-log decrease in the survival of probiotics in all of the yogurt treatments during a 30-d refrigerated storage period. Based on the results of the current study, only the polydextrose treatment would be an acceptable vehicle to deliver the probiotic health effects at the end of the 30-d storage period
Monday, October 4, 2010
Saturday, September 25, 2010
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